Abstract
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix. We review how the transcriptional regulators YAP and TAZ integrate mechanical cues with the response to soluble signals and metabolic pathways to control multiple aspects of cell behaviour, including proliferation, cell plasticity and stemness essential for tissue regeneration. Corruption of cell-environment interplay leads to aberrant YAP and TAZ activation that is instrumental for multiple diseases, including cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Cell Differentiation
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Cell Line
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Cell Plasticity
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Cell Proliferation
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Extracellular Matrix / genetics
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Extracellular Matrix / metabolism*
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Extracellular Matrix / pathology
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism*
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Mechanotransduction, Cellular*
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology
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Neoplastic Stem Cells / metabolism
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Neoplastic Stem Cells / pathology
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Phenotype
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Phosphoproteins / genetics
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Phosphoproteins / metabolism*
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Stem Cells / metabolism*
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Stem Cells / pathology
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Stress, Mechanical
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Trans-Activators
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Transcription Factors
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Transcriptional Coactivator with PDZ-Binding Motif Proteins
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Intracellular Signaling Peptides and Proteins
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Phosphoproteins
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Trans-Activators
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Transcription Factors
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Transcriptional Coactivator with PDZ-Binding Motif Proteins
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WWTR1 protein, human
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YAP-Signaling Proteins
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YAP1 protein, human