Trained Immunity and Local Innate Immune Memory in the Lung

Mihai G Netea; Leo A B Joosten

doi:10.1016/j.cell.2018.11.007

Trained Immunity and Local Innate Immune Memory in the Lung

Cell. 2018 Nov 29;175(6):1463-1465. doi: 10.1016/j.cell.2018.11.007.

Authors

Mihai G Netea¹, Leo A B Joosten²

Affiliations

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address: mihai.netea@radboudumc.nl.
² Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.

PMID: 30500533
DOI: 10.1016/j.cell.2018.11.007

Abstract

Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8⁺ lymphocytes initiating this process.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Immunity, Innate
Immunologic Memory*
Macrophages, Alveolar
T-Lymphocytes
Virus Diseases*