Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila

Laura Boulan; Ditte Andersen; Julien Colombani; Emilie Boone; Pierre Léopold

doi:10.1016/j.devcel.2019.03.016

Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila

Dev Cell. 2019 Jun 3;49(5):811-818.e4. doi: 10.1016/j.devcel.2019.03.016. Epub 2019 Apr 18.

Authors

Laura Boulan¹, Ditte Andersen², Julien Colombani², Emilie Boone², Pierre Léopold³

Affiliations

¹ Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne, 26 Rue d'Ulm, 75005 Paris, France. Electronic address: laura.boulan@curie.fr.
² Université Côte d'Azur, CNRS UMR7277, Inserm U1091, iBV, Parc Valrose, 06108 Nice, France.
³ Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne, 26 Rue d'Ulm, 75005 Paris, France. Electronic address: pierre.leopold@curie.fr.

PMID: 31006647
DOI: 10.1016/j.devcel.2019.03.016

Abstract

How organs scale with other body parts is not mechanistically understood. We have addressed this question using the Drosophila imaginal disc model. When the growth of one disc domain is perturbed, other parts of the disc and other discs slow down their growth, maintaining proper inter-disc and intra-disc proportions. We show here that the relaxin-like Dilp8 is required for this inter-organ coordination. Our work also reveals that the stress-response transcription factor Xrp1 plays a key role upstream of dilp8 in linking organ growth status with the systemic growth response. In addition, we show that the small ribosomal subunit protein RpS12 is required to trigger Xrp1-dependent non-autonomous response. Our work demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development.

Keywords: Dilp8; Drosophila; Minute; RpS12; Xrp1; coordination; organ growth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / genetics
Drosophila melanogaster / growth & development*
Drosophila melanogaster / metabolism
Female
Gene Expression Regulation, Developmental
Imaginal Discs / growth & development*
Imaginal Discs / metabolism
Intercellular Signaling Peptides and Proteins / genetics
Intercellular Signaling Peptides and Proteins / metabolism*
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism*
MAP Kinase Signaling System*
Male
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
Ribosomal Proteins / genetics
Ribosomal Proteins / metabolism*
Signal Transduction

Substances

DNA-Binding Proteins
Drosophila Proteins
Intercellular Signaling Peptides and Proteins
Intracellular Signaling Peptides and Proteins
Ribosomal Proteins
Xrp1 protein, Drosophila
insulin-like peptide 8, Drosophila
Protein Serine-Threonine Kinases
hpo protein, Drosophila