Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Affiliations

• ¹ MRC Laboratory of Molecular Biology, Cambridge, UK. gmasson@mrc-lmb.cam.ac.uk.
• ² Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. jeburke@uvic.ca.
• ³ Department of Biochemistry, University of Colorado, Boulder, CO, USA.
• ⁴ Department of Biological Science, National University of Singapore, Singapore, Singapore.
• ⁵ Genome BC Proteomics Centre, University of Victoria, Victoria, BC, Canada.
• ⁶ Institut Pasteur, Chemistry and Structural Biology Department, Paris, France.
• ⁷ Biogen Idec, Cambridge, MA, USA.
• ⁸ Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
• ⁹ Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
• ¹⁰ Novo Nordisk, Måløv, Denmark.
• ¹¹ UCB Celltech, Slough, UK.
• ¹² Department of Integrative Structural and Computational Biology, Scripps Florida, The Scripps Research Institute, Jupiter, FL, USA.
• ¹³ Department of Chemistry, Washington University in St. Louis, St. Louis, MO, USA.
• ¹⁴ Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, USA.
• ¹⁵ Johnson & Johnson Pharmaeutical Research and Development, Jersey City, NJ, USA.
• ¹⁶ Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, the Netherlands.
• ¹⁷ Codiak Biosciences, Cambridge, MA, USA.
• ¹⁸ Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej, Odense, Denmark.
• ¹⁹ Department of Chemistry, University of Massachusetts-Amherst, Amherst, MA, USA.
• ²⁰ Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
• ²¹ Department of Chemistry, The University of Western Ontario, London, ON, Canada.
• ²² Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
• ²³ Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA.
• ²⁴ Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
• ²⁵ MRC Laboratory of Molecular Biology, Cambridge, UK.
• ²⁶ Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA, USA.
• ²⁷ Roche Innovation Center Penzberg, Penzberg, Germany.
• ²⁸ Department of Early Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, CA, USA.
• ²⁹ Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, USA.
• ³⁰ Department of Chemistry, York University, Toronto, ON, Canada.
• ³¹ Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, USA.
• ³² Process Development, Amgen, Thousand Oaks, CA, USA.
• ³³ Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB, Canada. dschriem@ucalgary.ca.
• ³⁴ Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark. kasper.rand@sund.ku.dk.