The Hippo Signaling Pathway in Development and Disease

Dev Cell. 2019 Aug 5;50(3):264-282. doi: 10.1016/j.devcel.2019.06.003.

Abstract

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Keywords: NF2; TAZ; TEAD; YAP; actomyosin; adherens junction; cancer; cell polarity; cytoskeleton; growth control; hippo signaling; mechanotransduction; merlin; neurofibromatosis; oncogene; regeneration; scalloped; spectrin; tissue homeostasis; tumor suppressor; yorkie.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Exosome Multienzyme Ribonuclease Complex / genetics*
  • Exosome Multienzyme Ribonuclease Complex / metabolism
  • Gene Expression Regulation, Developmental*
  • Humans
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Signal Transduction*
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism

Substances

  • Cell Cycle Proteins
  • Transcription Factors
  • YY1AP1 protein, human
  • Exosome Multienzyme Ribonuclease Complex
  • DIS3 protein, human