Common brain disorders are associated with heritable patterns of apparent aging of the brain

Nat Neurosci. 2019 Oct;22(10):1617-1623. doi: 10.1038/s41593-019-0471-7. Epub 2019 Sep 24.

Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / genetics*
  • Aging / pathology*
  • Algorithms
  • Brain / diagnostic imaging
  • Brain / growth & development*
  • Brain Diseases / diagnostic imaging*
  • Brain Diseases / genetics*
  • Child
  • Child, Preschool
  • Female
  • Genome-Wide Association Study
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Mental Disorders / diagnostic imaging
  • Mental Disorders / genetics
  • Middle Aged
  • Neuropsychological Tests
  • Schizophrenia / genetics
  • Schizophrenia / pathology
  • Sex Characteristics
  • Young Adult