A developmental landscape of 3D-cultured human pre-gastrulation embryos

Nature. 2020 Jan;577(7791):537-542. doi: 10.1038/s41586-019-1875-y. Epub 2019 Dec 12.

Abstract

Our understanding of how human embryos develop before gastrulation, including spatial self-organization and cell type ontogeny, remains limited by available two-dimensional technological platforms1,2 that do not recapitulate the in vivo conditions3-5. Here we report a three-dimensional (3D) blastocyst-culture system that enables human blastocyst development up to the primitive streak anlage stage. These 3D embryos mimic developmental landmarks and 3D architectures in vivo, including the embryonic disc, amnion, basement membrane, primary and primate unique secondary yolk sac, formation of anterior-posterior polarity and primitive streak anlage. Using single-cell transcriptome profiling, we delineate ontology and regulatory networks that underlie the segregation of epiblast, primitive endoderm and trophoblast. Compared with epiblasts, the amniotic epithelium shows unique and characteristic phenotypes. After implantation, specific pathways and transcription factors trigger the differentiation of cytotrophoblasts, extravillous cytotrophoblasts and syncytiotrophoblasts. Epiblasts undergo a transition to pluripotency upon implantation, and the transcriptome of these cells is maintained until the generation of the primitive streak anlage. These developmental processes are driven by different pluripotency factors. Together, findings from our 3D-culture approach help to determine the molecular and morphogenetic developmental landscape that occurs during human embryogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amnion / cytology
  • Amnion / embryology
  • Blastocyst / cytology
  • Cell Culture Techniques / methods*
  • Cell Differentiation
  • Cell Lineage
  • Cell Polarity
  • Collagen
  • Drug Combinations
  • Embryo, Mammalian / cytology*
  • Embryo, Mammalian / embryology*
  • Embryonic Development*
  • Epithelium / embryology
  • Gastrulation
  • Germ Layers / cytology
  • Germ Layers / embryology
  • Humans
  • Laminin
  • Primitive Streak / cytology*
  • Primitive Streak / embryology*
  • Proteoglycans
  • RNA-Seq
  • Single-Cell Analysis
  • Transcription Factors / metabolism
  • Transcriptome
  • Trophoblasts / cytology
  • Yolk Sac / cytology
  • Yolk Sac / embryology

Substances

  • Drug Combinations
  • Laminin
  • Proteoglycans
  • Transcription Factors
  • matrigel
  • Collagen