The exponential growth in the number of newly solved protein structures makes correlating and classifying the data an important task. Distance matrix alignment (Dali) is used routinely by crystallographers worldwide to screen the database of known structures for similarity to newly determined structures. Dali is easily accessible through the web server ( http://ekhidna.biocenter.helsinki.fi/dali ). Alternatively, the program may be downloaded and pairwise comparisons performed locally on Linux computers.
Keywords: Classification of protein folds; Database searching; Distance geometry; Pattern recognition; Protein structure alignment.