Abstract
A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective infection by LDV of I-region-associated antigen- (Ia) positive macrophages.
MeSH terms
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Animals
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Encephalomyelitis, Autoimmune, Experimental / immunology*
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Encephalomyelitis, Autoimmune, Experimental / microbiology
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Encephalomyelitis, Autoimmune, Experimental / prevention & control
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Histocompatibility Antigens Class II / immunology
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Immunity, Cellular
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Immunization
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Lactate dehydrogenase-elevating virus / immunology*
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Male
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Mice
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Spinal Cord / immunology
Substances
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Histocompatibility Antigens Class II