The purpose of this study was to investigate whether subjects who self-report high levels of stress have lower immunity, and whether "low"-immunity subjects under "high" stress could enhance phagocytic activity through biofeedback-assisted relaxation (BAR). During Phase 1, the level of stress and the level of phagocytic immune functioning (nitroblue tetrazolium test) were assessed as "high" or "low." Significant chi-square analysis (chi 2 = 3.8624, df = 1, p less than .05) showed that subjects with "high" stress had "low" immunity. Sixteen "high"-stress, "low"-immunity subjects were randomly assigned to BAR and control groups during Phase 2. Following treatment, NBT changes showed significant increases (F = 11.11, p less than .003) for experimental group as compared to control group. White blood cell count and white blood cell differential were unchanged across blood samples for both groups. Experimental subjects reported significant decreases in tension-anxiety and increases in overall coping. BAR was concluded to have improved coping skills and phagocytic capacity. BAR affected the quality, rather than the quantity, of phagocytic neutrophils.