Only one of two closely related yeast suppressor tRNA genes contains an intervening sequence

Nature. 1981 Jun 11;291(5815):464-9. doi: 10.1038/291464a0.

Abstract

The yeast genes that code for the serine-inserting SUP-RL1 amber and SUQ5 ochre suppressors have been cloned and sequenced. These two unlinked genes differ by only three base pairs in their coding regions yet they encode tRNAs of different translational specificities, and while the SUP-RL1 gene has a 19-base pair intervening sequence, the SUQ5 gene has none.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • DNA Restriction Enzymes
  • Mutation
  • Nucleic Acid Hybridization
  • RNA, Transfer / genetics*
  • Saccharomyces cerevisiae / genetics*
  • Suppression, Genetic*

Substances

  • RNA, Transfer
  • DNA Restriction Enzymes

Associated data

  • GENBANK/K00367
  • GENBANK/K00368
  • GENBANK/K00571
  • GENBANK/K00572