Abstract
Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Cell Line
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Cell Transformation, Neoplastic
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DNA Restriction Enzymes
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DNA, Neoplasm / genetics*
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DNA, Viral / genetics*
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Genes*
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Genes, Viral*
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Humans
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Mice
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Nucleic Acid Hybridization
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Oncogenic Viruses / genetics*
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Sarcoma Viruses, Murine / genetics*
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Species Specificity
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Transcription, Genetic
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Urinary Bladder Neoplasms / genetics*
Substances
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DNA, Neoplasm
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DNA, Viral
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DNA Restriction Enzymes