Immediate-early genes induced by antigen receptor stimulation

Curr Opin Immunol. 1995 Jun;7(3):327-32. doi: 10.1016/0952-7915(95)80106-5.

Abstract

Immediate early genes induced by triggering of the TCR frequently encode proteins that act in signal transduction cascades. Recent advances concerning several immediate-early proteins have been made, including signal-induced regulation of NF-kappa B by I kappa-B, the role of Nur77 in T-cell selection and apoptosis, and the function of PAC-1 in regulating the Ras/ERK pathway.

Publication types

  • Review

MeSH terms

  • Calcium-Calmodulin-Dependent Protein Kinases / genetics
  • Calcium-Calmodulin-Dependent Protein Kinases / immunology
  • Down-Regulation
  • Dual Specificity Phosphatase 2
  • Extracellular Signal-Regulated MAP Kinases*
  • Gene Expression
  • Genes, Immediate-Early / genetics*
  • Genes, Immediate-Early / immunology
  • Humans
  • MAP Kinase Kinase Kinases*
  • Models, Genetic
  • Models, Immunological
  • Protein Phosphatase 2
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / immunology
  • Receptors, Antigen / genetics*
  • Receptors, Antigen / immunology
  • Signal Transduction
  • Transcription Factors

Substances

  • Receptors, Antigen
  • Transcription Factors
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Extracellular Signal-Regulated MAP Kinases
  • MAP Kinase Kinase Kinases
  • Ras-dependent mitogen-activated protein kinase kinase kinase
  • Protein Phosphatase 2
  • DUSP2 protein, human
  • Dual Specificity Phosphatase 2
  • Protein Tyrosine Phosphatases