Abstract
Immediate early genes induced by triggering of the TCR frequently encode proteins that act in signal transduction cascades. Recent advances concerning several immediate-early proteins have been made, including signal-induced regulation of NF-kappa B by I kappa-B, the role of Nur77 in T-cell selection and apoptosis, and the function of PAC-1 in regulating the Ras/ERK pathway.
MeSH terms
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Calcium-Calmodulin-Dependent Protein Kinases / genetics
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Calcium-Calmodulin-Dependent Protein Kinases / immunology
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Down-Regulation
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Dual Specificity Phosphatase 2
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Extracellular Signal-Regulated MAP Kinases*
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Gene Expression
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Genes, Immediate-Early / genetics*
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Genes, Immediate-Early / immunology
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Humans
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MAP Kinase Kinase Kinases*
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Models, Genetic
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Models, Immunological
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Protein Phosphatase 2
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Protein Tyrosine Phosphatases / genetics
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Protein Tyrosine Phosphatases / immunology
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Receptors, Antigen / genetics*
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Receptors, Antigen / immunology
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Signal Transduction
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Transcription Factors
Substances
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Receptors, Antigen
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Transcription Factors
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Calcium-Calmodulin-Dependent Protein Kinases
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Extracellular Signal-Regulated MAP Kinases
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MAP Kinase Kinase Kinases
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Ras-dependent mitogen-activated protein kinase kinase kinase
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Protein Phosphatase 2
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DUSP2 protein, human
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Dual Specificity Phosphatase 2
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Protein Tyrosine Phosphatases