Abstract
Male-specific lethal-2 (msl-2) is a RING finger protein that is required for X chromosome dosage compensation in Drosophila males. Consistent with the formation of a dosage compensation protein complex, msl-2 colocalizes with the other MSL proteins on the male X chromosome and coimmunoprecipitates with msl-1 from male larval extracts. Ectopic expression of msl-2 in females results in the appearance of the other MSL dosage compensation regulators on the female X chromosomes and decreased female viability. We suggest that msl-2 RNA is the primary target of SxI regulation in the dosage compensation pathway and present a speculative model for the regulation of two distinct modes of dosage compensation by SxI.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping
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DNA / genetics
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DNA Primers / genetics
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DNA-Binding Proteins
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Dosage Compensation, Genetic*
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Drosophila / genetics
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Drosophila Proteins
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Female
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Gene Expression
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Genes, Insect
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Genes, Lethal
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Male
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Models, Genetic
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Molecular Sequence Data
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Nuclear Proteins / genetics*
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Protein Biosynthesis
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Sex Characteristics
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Transcription Factors / genetics*
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X Chromosome
Substances
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DNA Primers
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DNA-Binding Proteins
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Drosophila Proteins
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Nuclear Proteins
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Transcription Factors
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msl-2 protein, Drosophila
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DNA
Associated data
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GENBANK/L42514
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GENBANK/L42553