Abstract
RNA editing in mitochondria of kinetoplastid protozoa involves the posttranscriptional insertion and deletion of uridylate residues in protein encoding regions of pre-mRNAs. Editing is required to remove gene-encoded translational defects or to convert a nonsense sequence into a sense message. In cultured trypanosomatids, however, translationally defective pre-mRNAs for a number of NADH-dehydrogenase subunits are not converted into functional mRNAs by editing. In this report, the available data are discussed in the context of current models for RNA editing.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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DNA, Complementary / genetics
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DNA, Mitochondrial / genetics
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DNA, Protozoan / genetics
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Mitochondria / metabolism
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Models, Biological
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Molecular Sequence Data
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NADH Dehydrogenase / genetics*
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RNA Editing* / genetics
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RNA Precursors / genetics
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RNA Precursors / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Protozoan / genetics
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RNA, Protozoan / metabolism
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Trypanosomatina / genetics*
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Trypanosomatina / metabolism*
Substances
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DNA, Complementary
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DNA, Mitochondrial
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DNA, Protozoan
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RNA Precursors
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RNA, Messenger
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RNA, Protozoan
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NADH Dehydrogenase