Abstract
We have identified a putative Drosophila STAT protein named Marelle that exhibits mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show that a reduction in the amount of marelle gene activity suppresses the phenotype associated with a gain-of-function mutation in hopscotch and enhances the phenotype associated with a weak hopscotch mutation. We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cloning, Molecular
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DNA / genetics
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DNA-Binding Proteins / genetics*
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Drosophila / embryology
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Drosophila / genetics*
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Drosophila Proteins
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Female
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Genes, Insect
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Janus Kinases
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Male
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Models, Genetic
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Molecular Sequence Data
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Mutation
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Phenotype
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Protein-Tyrosine Kinases / genetics*
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Sequence Homology, Amino Acid
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Signal Transduction / genetics
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Suppression, Genetic
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Trans-Activators / genetics*
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Transcription Factors
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Trans-Activators
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Transcription Factors
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DNA
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Protein-Tyrosine Kinases
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Janus Kinases
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hop protein, Drosophila