Abstract
The effect of 5-HT1 and 5-HT2 receptor agonists administered into the paraventricular hypothalamus was studied on the hyperphagia caused by neuropeptide Y (NPY) injected into the same area. The 5-HT2A/2C receptor agonist DOI (10-20 nmol/0.5 microliter) significantly reduced NPY overeating while the 5-HT1A/1B receptor agonist RU 24969 (3.5-14 nmol/0.5 microliter) and the 5-HT1B/2C receptor agonist mCPP (5-20 nmol/0.5 microliter) had no such effect. The 5-HT2A receptor antagonist spiperone (5 microgram/0.5 microliter) and the corticotropin releasing factor antagonist alpha-helical-CRF9-41 (0.5-1 micrograms/0.5 microliter) completely antagonized the effect of 10 nmol DOI.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphetamines / pharmacology
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Animals
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Corticotropin-Releasing Hormone / physiology*
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Feeding Behavior / drug effects
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Feeding Behavior / physiology
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Hyperphagia*
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Indoles / pharmacology
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Male
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Neuropeptide Y / pharmacology*
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Paraventricular Hypothalamic Nucleus
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Piperazines / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / physiology*
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Serotonin Receptor Agonists / pharmacology*
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Spiperone / pharmacology
Substances
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Amphetamines
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Indoles
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Neuropeptide Y
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Piperazines
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin
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Serotonin Receptor Agonists
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1-(3-trifluoromethylphenyl)piperazine
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5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole
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Spiperone
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Corticotropin-Releasing Hormone
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4-iodo-2,5-dimethoxyphenylisopropylamine