Reading between the lines: SH3 recognition of an intact protein

W A Lim

doi:10.1016/s0969-2126(96)00071-8

Reading between the lines: SH3 recognition of an intact protein

Structure. 1996 Jun 15;4(6):657-9. doi: 10.1016/s0969-2126(96)00071-8.

Author

W A Lim¹

Affiliation

¹ Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA.

PMID: 8805558
DOI: 10.1016/s0969-2126(96)00071-8

Abstract

The structure of Nef-SH3 domain complex reveals how an SH3 domain can more effectively 'read' its linear proline-rich recognition element when it is presented within the context of a folded protein.

Publication types

Review

MeSH terms

Binding Sites
Conserved Sequence / genetics
Gene Products, nef / chemistry*
Gene Products, nef / metabolism
Models, Molecular
Protein Binding
Protein Conformation
Protein Structure, Secondary
Protein-Tyrosine Kinases / chemistry
Protein-Tyrosine Kinases / metabolism
Proto-Oncogene Proteins / chemistry
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-hck
src Homology Domains / genetics*

Substances

Gene Products, nef
Proto-Oncogene Proteins
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-hck