Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice

Brain Res Dev Brain Res. 1996 Aug 20;95(1):131-4. doi: 10.1016/0165-3806(96)00087-9.

Abstract

We studied the ontogenetic response to cannabinoid receptor ligands by measuring motor activity and analgesia in response to anandamide or delta 9-THC from day 6 of age. No response to anandamide was observed up to the age of weaning (day 23), while a nonsignificant response to delta 9-THC was observed starting between days 15 and 20. This is compatible with observations that children respond to the antiemetic effects of THC without psychotropic side effects.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / physiology*
  • Analgesics, Non-Narcotic / pharmacology*
  • Animals
  • Arachidonic Acids / pharmacology*
  • Cannabinoids / metabolism*
  • Dronabinol / pharmacology*
  • Endocannabinoids
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity / drug effects*
  • Pain Measurement / drug effects
  • Polyunsaturated Alkamides

Substances

  • Analgesics, Non-Narcotic
  • Arachidonic Acids
  • Cannabinoids
  • Endocannabinoids
  • Polyunsaturated Alkamides
  • Dronabinol
  • anandamide