Abstract
We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amygdala / chemistry
-
Amygdala / cytology
-
Animals
-
Cerebral Cortex / chemistry
-
Cerebral Cortex / cytology*
-
Dentate Gyrus / chemistry
-
Dentate Gyrus / cytology*
-
Immunohistochemistry
-
In Situ Hybridization
-
Interneurons / chemistry*
-
Interneurons / physiology
-
Male
-
Olfactory Bulb / chemistry
-
Olfactory Bulb / cytology
-
Rats
-
Rats, Sprague-Dawley
-
Receptors, Serotonin / analysis
-
Receptors, Serotonin / biosynthesis
-
Receptors, Serotonin / genetics*
-
Septal Nuclei / chemistry
-
Septal Nuclei / cytology
-
gamma-Aminobutyric Acid / physiology*
Substances
-
Receptors, Serotonin
-
gamma-Aminobutyric Acid