Abstract
We have identified two genes, roX1 and roX2, whose expression in the adult fly is restricted to neurons of males. The two genes reside on the X chromosome, and each encodes an RNA with no apparent open reading frame. Both genes are physically linked to female-specific genes that encode proteins expressed in the ovary: opt1, a novel peptide transporter, and nod, a member of the kinesin family. The male-specific transcripts are positively regulated by the dosage compensation pathway in an all-or-none fashion. Our data suggest that the multimeric complex of dosage compensation proteins may operate in different ways on different sets of X-linked genes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Animals
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Brain / cytology
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DNA, Complementary / analysis
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Drosophila Proteins*
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Drosophila melanogaster / genetics*
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Female
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Ganglia, Invertebrate / cytology
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Gene Dosage
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Gene Expression / physiology
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Gene Expression Regulation, Developmental / physiology
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Gene Library
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Genes, Insect / physiology*
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Genetic Linkage
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Insect Hormones / genetics
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Male
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Molecular Sequence Data
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Neurons / physiology*
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Nuclear Proteins / genetics
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Peripheral Nervous System / cytology
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RNA, Messenger / analysis
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RNA, Messenger / physiology
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RNA-Binding Proteins / genetics
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Sequence Homology, Amino Acid
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Sex Determination Analysis
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Transcription, Genetic / physiology
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X Chromosome
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Y Chromosome
Substances
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DNA, Complementary
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Drosophila Proteins
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Insect Hormones
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Nuclear Proteins
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Pabp2 protein, Drosophila
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RNA, Messenger
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RNA-Binding Proteins
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Tra protein, Drosophila
Associated data
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GENBANK/U85980
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GENBANK/U85981
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GENBANK/U85982