The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

E Rosengren; P Aman; S Thelin; C Hansson; S Ahlfors; P Björk; L Jacobsson; H Rorsman

doi:10.1016/s0014-5793(97)01261-1

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

FEBS Lett. 1997 Nov 3;417(1):85-8. doi: 10.1016/s0014-5793(97)01261-1.

Authors

E Rosengren¹, P Aman, S Thelin, C Hansson, S Ahlfors, P Björk, L Jacobsson, H Rorsman

Affiliation

¹ Department of Pharmacology, University of Lund, Sweden.

PMID: 9395080
DOI: 10.1016/s0014-5793(97)01261-1

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / analysis
Animals
Cattle
Humans
Indolequinones*
Indoles / metabolism
Intramolecular Oxidoreductases / chemistry
Intramolecular Oxidoreductases / metabolism*
Intramolecular Oxidoreductases / pharmacology
Macrophage Migration-Inhibitory Factors / chemistry
Macrophage Migration-Inhibitory Factors / metabolism*
Macrophage Migration-Inhibitory Factors / pharmacology
Phenylpyruvic Acids / metabolism*
Quinones / metabolism
Recombinant Fusion Proteins / chemistry
Recombinant Fusion Proteins / metabolism
Recombinant Fusion Proteins / pharmacology
Substrate Specificity

Substances

Amino Acids
Indolequinones
Indoles
Macrophage Migration-Inhibitory Factors
Phenylpyruvic Acids
Quinones
Recombinant Fusion Proteins
4-hydroxyphenylpyruvic acid
dopachrome
5,6-dihydroxy-2-indolylcarboxylic acid
Intramolecular Oxidoreductases
phenylpyruvate tautomerase
phenylpyruvic acid