A CTD function linking transcription to splicing

Trends Biochem Sci. 1997 Nov;22(11):413-6. doi: 10.1016/s0968-0004(97)01125-0.

Abstract

Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / genetics*
  • RNA Precursors / genetics*
  • RNA Splicing*
  • Transcription, Genetic*

Substances

  • RNA Precursors
  • RNA Polymerase II