Abstract
G protein alpha-subunits (G alpha) undergo palmitoylation and/or myristoylation. This review will focus on new insights into the function and regulation of these fatty acid modifications of G alpha. Most importantly, I will examine lipid modifications of G alpha in the context of a two-signal model for membrane attachment, discuss recent advances in the identification of palmitoyl transferases, and highlight several controversial issues in this field.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Membrane / enzymology
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Cell Membrane / metabolism
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GTP-Binding Proteins / metabolism*
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Humans
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Lipid Metabolism*
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Lipids / physiology
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Membrane Proteins / metabolism*
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Membrane Proteins / physiology
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Models, Biological
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Molecular Sequence Data
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Myristic Acid / metabolism
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Palmitic Acid / metabolism
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Signal Transduction
Substances
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Lipids
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Membrane Proteins
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Myristic Acid
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Palmitic Acid
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GTP-Binding Proteins