Abstract
A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is currently known about the AP-3 complex and discuss recent insight into its function in multicellular organisms that has come from the finding that mutations in AP-3 subunits correspond to classical mutations in Drosophila and mice.
MeSH terms
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Adaptor Proteins, Vesicular Transport
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Animals
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Biological Transport / physiology
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Enzyme Inhibitors / metabolism*
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Eukaryotic Cells / chemistry
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Eukaryotic Cells / metabolism
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Golgi Apparatus / chemistry
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Golgi Apparatus / metabolism*
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Lysosomes / chemistry
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Lysosomes / metabolism*
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Monomeric Clathrin Assembly Proteins*
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Nerve Tissue Proteins / physiology*
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Phosphoproteins / physiology*
Substances
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Adaptor Proteins, Vesicular Transport
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Enzyme Inhibitors
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Monomeric Clathrin Assembly Proteins
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Nerve Tissue Proteins
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Phosphoproteins
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clathrin assembly protein AP180