Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root

J F Liao; H H Wang; M C Chen; C C Chen; C F Chen

doi:10.1055/s-2006-957517

Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root

Planta Med. 1998 Aug;64(6):571-2. doi: 10.1055/s-2006-957517.

Authors

J F Liao¹, H H Wang, M C Chen, C C Chen, C F Chen

Affiliation

¹ Department of Pharmacology, National Yang-Ming University, Taipei, Taiwan, Republic of China.

PMID: 9776664
DOI: 10.1055/s-2006-957517

Abstract

A benzodiazepine binding assay directed separation led to the identification of 3 flavones baicalein (1), oroxylin A (2), and skullcapflavone II (3) from the water extract of Scutellaria baicalensis root. Compounds 1, 2, and 3 interacted with the benzodiazepine binding site of GABAA receptors with a Ki value of 13.1, 14.6 and 0.36 micromol/L, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Binding, Competitive
Cell Membrane / metabolism
Cerebral Cortex / metabolism
Drugs, Chinese Herbal / chemistry
Flavonoids / chemistry
Flavonoids / isolation & purification*
Flavonoids / pharmacology*
Flunitrazepam / metabolism
Mice
Mice, Inbred ICR
Molecular Structure
Plant Roots
Plants, Medicinal*
Receptors, GABA-A / metabolism*

Substances

Drugs, Chinese Herbal
Flavonoids
Receptors, GABA-A
Flunitrazepam