Abstract
The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.
MeSH terms
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Alternative Splicing
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Amino Acid Sequence
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Carrier Proteins / analysis
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Carrier Proteins / physiology*
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Cell Nucleus / metabolism
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Exportin 1 Protein
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Gene Expression Regulation, Viral
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Gene Products, rev / analysis
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Gene Products, rev / genetics
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Gene Products, rev / metabolism
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Gene Products, rev / physiology*
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HIV Infections / therapy
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HIV-1 / chemistry*
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Humans
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Karyopherins*
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Molecular Sequence Data
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RNA, Messenger / metabolism
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RNA, Viral / chemistry
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RNA, Viral / metabolism
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Receptors, Cytoplasmic and Nuclear*
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Trans-Activators
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rev Gene Products, Human Immunodeficiency Virus
Substances
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Carrier Proteins
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Gene Products, rev
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Karyopherins
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RNA, Messenger
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RNA, Viral
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Receptors, Cytoplasmic and Nuclear
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Trans-Activators
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rev Gene Products, Human Immunodeficiency Virus