Abstract
The number of known three-dimensional structures of vitamin B6-dependent enzymes has doubled in the past two years. A fourth type of fold for B6-dependent enzymes, involving a TIM-barrel domain, has been discovered. Alanine racemase is the first known representative of this new fold. Significant progress has been made in understanding the allosteric effects in the tryptophan synthase reaction.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alanine Racemase / chemistry*
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Alanine Racemase / metabolism
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Alanine Transaminase / chemistry*
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Alanine Transaminase / metabolism
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Aspartate Aminotransferases / chemistry*
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Aspartate Aminotransferases / metabolism
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D-Alanine Transaminase
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Models, Molecular
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Protein Conformation
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Pyridoxine / metabolism*
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Tryptophan Synthase / chemistry*
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Tryptophan Synthase / metabolism
Substances
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Aspartate Aminotransferases
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Alanine Transaminase
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D-Alanine Transaminase
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Tryptophan Synthase
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Alanine Racemase
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Pyridoxine