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Page 1
Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells.
Nucleic Acids Res. 2023 Aug 11;51(14):7392-7408. doi: 10.1093/nar/gkad535.
Nucleic Acids Res. 2023.
PMID: 37351621
Free PMC article.
Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis.
Ianevski A, Kulesskiy E, Krpina K, Lou G, Aman Y, Bugai A, Aasumets K, Akimov Y, Bulanova D, Gildemann K, Arutyunyan AF, Susova OY, Zhuze AL, Ji P, Wang W, Holien T, Bugge M, Zusinaite E, Oksenych V, Lysvand H, Gerhold JM, Bjørås M, Johansen P, Waage A, Heckman CA, Fang EF, Kainov DE.
Ianevski A, et al. Among authors: aasumets k.
Cancers (Basel). 2020 Jun 25;12(6):1694. doi: 10.3390/cancers12061694.
Cancers (Basel). 2020.
PMID: 32630560
Free PMC article.
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Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.
Hangas A, Aasumets K, Kekäläinen NJ, Paloheinä M, Pohjoismäki JL, Gerhold JM, Goffart S.
Hangas A, et al. Among authors: aasumets k.
Nucleic Acids Res. 2018 Oct 12;46(18):9625-9636. doi: 10.1093/nar/gky793.
Nucleic Acids Res. 2018.
PMID: 30169847
Free PMC article.
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Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.
Wagner A, Hofmeister O, Rolland SG, Maiser A, Aasumets K, Schmitt S, Schorpp K, Feuchtinger A, Hadian K, Schneider S, Zischka H, Leonhardt H, Conradt B, Gerhold JM, Wolf A.
Wagner A, et al. Among authors: aasumets k.
J Cell Sci. 2019 Oct 1;132(19):jcs223891. doi: 10.1242/jcs.223891.
J Cell Sci. 2019.
PMID: 31434717
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TFAM knockdown-triggered mtDNA-nucleoid aggregation and a decrease in mtDNA copy number induce the reorganization of nucleoid populations and mitochondria-associated ER-membrane contacts.
Aasumets K, Basikhina Y, Pohjoismäki JL, Goffart S, Gerhold J.
Aasumets K, et al.
Biochem Biophys Rep. 2021 Sep 24;28:101142. doi: 10.1016/j.bbrep.2021.101142. eCollection 2021 Dec.
Biochem Biophys Rep. 2021.
PMID: 34622037
Free PMC article.
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