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The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.
JCI Insight. 2018 Oct 4;3(19):e99306. doi: 10.1172/jci.insight.99306.
JCI Insight. 2018.
PMID: 30282826
Free PMC article.
Clinical Trial.
Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).
Heywood J, Evangelou M, Goymer D, Kennet J, Anselmiova K, Guy C, O'Brien C, Nutland S, Brown J, Walker NM, Todd JA, Waldron-Lynch F.
Heywood J, et al. Among authors: anselmiova k.
Trials. 2015 Mar 11;16:86. doi: 10.1186/s13063-015-0583-7.
Trials. 2015.
PMID: 25881192
Free PMC article.
Clinical Trial.
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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
Todd JA, Evangelou M, Cutler AJ, Pekalski ML, Walker NM, Stevens HE, Porter L, Smyth DJ, Rainbow DB, Ferreira RC, Esposito L, Hunter KM, Loudon K, Irons K, Yang JH, Bell CJ, Schuilenburg H, Heywood J, Challis B, Neupane S, Clarke P, Coleman G, Dawson S, Goymer D, Anselmiova K, Kennet J, Brown J, Caddy SL, Lu J, Greatorex J, Goodfellow I, Wallace C, Tree TI, Evans M, Mander AP, Bond S, Wicker LS, Waldron-Lynch F.
Todd JA, et al. Among authors: anselmiova k.
PLoS Med. 2016 Oct 11;13(10):e1002139. doi: 10.1371/journal.pmed.1002139. eCollection 2016 Oct.
PLoS Med. 2016.
PMID: 27727279
Free PMC article.
Clinical Trial.
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