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An allosteric HTRA1-calpain 2 complex with restricted activation profile.
Rey J, Breiden M, Lux V, Bluemke A, Steindel M, Ripkens K, Möllers B, Bravo Rodriguez K, Boisguerin P, Volkmer R, Mieres-Perez J, Clausen T, Sanchez-Garcia E, Ehrmann M. Rey J, et al. Among authors: breiden m. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2113520119. doi: 10.1073/pnas.2113520119. Epub 2022 Mar 29. Proc Natl Acad Sci U S A. 2022. PMID: 35349341 Free PMC article.
Human serine protease HTRA1 positively regulates osteogenesis of human bone marrow-derived mesenchymal stem cells and mineralization of differentiating bone-forming cells through the modulation of extracellular matrix protein.
Tiaden AN, Breiden M, Mirsaidi A, Weber FA, Bahrenberg G, Glanz S, Cinelli P, Ehrmann M, Richards PJ. Tiaden AN, et al. Among authors: breiden m. Stem Cells. 2012 Oct;30(10):2271-82. doi: 10.1002/stem.1190. Stem Cells. 2012. PMID: 22865667