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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase.
Sci Rep. 2023 Jun 6;13(1):9161. doi: 10.1038/s41598-023-35907-w.
Sci Rep. 2023.
PMID: 37280236
Free PMC article.
Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action.
Macegoniuk K, Tabor W, Mazzei L, Cianci M, Giurg M, Olech K, Burda-Grabowska M, Kaleta R, Grabowiecka A, Mucha A, Ciurli S, Berlicki Ł.
Macegoniuk K, et al. Among authors: burda grabowska m.
J Med Chem. 2023 Feb 9;66(3):2054-2063. doi: 10.1021/acs.jmedchem.2c01799. Epub 2023 Jan 20.
J Med Chem. 2023.
PMID: 36661843
Free PMC article.
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Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2.
Weglarz-Tomczak E, Tomczak JM, Talma M, Burda-Grabowska M, Giurg M, Brul S.
Weglarz-Tomczak E, et al. Among authors: burda grabowska m.
Sci Rep. 2021 Feb 11;11(1):3640. doi: 10.1038/s41598-021-83229-6.
Sci Rep. 2021.
PMID: 33574416
Free PMC article.
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Bisphosphonic acids and related compounds as inhibitors of nucleotide- and polyphosphate-processing enzymes: A PPK1 and PPK2 case study.
Burda-Grabowska M, Macegoniuk K, Flick R, Nocek BP, Joachimiak A, Yakunin AF, Mucha A, Berlicki Ł.
Burda-Grabowska M, et al.
Chem Biol Drug Des. 2019 Jun;93(6):1197-1206. doi: 10.1111/cbdd.13439. Epub 2018 Nov 28.
Chem Biol Drug Des. 2019.
PMID: 30484959
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Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.
Węglarz-Tomczak E, Burda-Grabowska M, Giurg M, Mucha A.
Węglarz-Tomczak E, et al. Among authors: burda grabowska m.
Bioorg Med Chem Lett. 2016 Nov 1;26(21):5254-5259. doi: 10.1016/j.bmcl.2016.09.050. Epub 2016 Sep 20.
Bioorg Med Chem Lett. 2016.
PMID: 27692546
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