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On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging.
Dang H, Castro-Portuguez R, Espejo L, Backer G, Freitas S, Spence E, Meyers J, Shuck K, Gardea EA, Chang LM, Balsa J, Thorns N, Corban C, Liu T, Bean S, Sheehan S, Korstanje R, Sutphin GL. Dang H, et al. Among authors: castro portuguez r. Nat Commun. 2023 Dec 14;14(1):8338. doi: 10.1038/s41467-023-43527-1. Nat Commun. 2023. PMID: 38097593 Free PMC article.
Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning.
Watson AW, Grant AD, Parker SS, Hill S, Whalen MB, Chakrabarti J, Harman MW, Roman MR, Forte BL, Gowan CC, Castro-Portuguez R, Stolze LK, Franck C, Cusanovich DA, Zavros Y, Padi M, Romanoski CE, Mouneimne G. Watson AW, et al. Among authors: castro portuguez r. Cell Rep. 2021 Jun 29;35(13):109293. doi: 10.1016/j.celrep.2021.109293. Cell Rep. 2021. PMID: 34192535 Free PMC article.
Low-level arsenic causes proteotoxic stress and not oxidative stress.
Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. Dodson M, et al. Among authors: castro portuguez r. Toxicol Appl Pharmacol. 2018 Feb 15;341:106-113. doi: 10.1016/j.taap.2018.01.014. Epub 2018 Feb 3. Toxicol Appl Pharmacol. 2018. PMID: 29408041 Free PMC article.
The Emerging Role of 3-Hydroxyanthranilic Acid on C. elegans Aging Immune Function.
Espejo LS, DeNicola D, Chang LM, Hofschneider V, Haskins AE, Balsa J, Freitas SS, Antenor A, Hamming S, Hull B, Castro-Portuguez R, Dang H, Sutphin GL. Espejo LS, et al. Among authors: castro portuguez r. bioRxiv [Preprint]. 2024 Jan 9:2024.01.07.574394. doi: 10.1101/2024.01.07.574394. bioRxiv. 2024. PMID: 38260592 Free PMC article. Preprint.