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Page 1
CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer.
Filippone MG, Gaglio D, Bonfanti R, Tucci FA, Ceccacci E, Pennisi R, Bonanomi M, Jodice G, Tillhon M, Montani F, Bertalot G, Freddi S, Vecchi M, Taglialatela A, Romanenghi M, Romeo F, Bianco N, Munzone E, Sanguedolce F, Vago G, Viale G, Di Fiore PP, Minucci S, Alberghina L, Colleoni M, Veronesi P, Tosoni D, Pece S. Filippone MG, et al. Among authors: ceccacci e. Nat Commun. 2022 May 12;13(1):2642. doi: 10.1038/s41467-022-30375-8. Nat Commun. 2022. PMID: 35550508 Free PMC article. Clinical Trial.
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response.
Faletti S, Osti D, Ceccacci E, Richichi C, Costanza B, Nicosia L, Noberini R, Marotta G, Furia L, Faretta MR, Brambillasca S, Quarto M, Bertero L, Boldorini R, Pollo B, Gandini S, Cora D, Minucci S, Mercurio C, Varasi M, Bonaldi T, Pelicci G. Faletti S, et al. Among authors: ceccacci e. Sci Transl Med. 2021 Dec 8;13(623):eabf7036. doi: 10.1126/scitranslmed.abf7036. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878824
KIT Is Required for Fetal Liver Hematopoiesis.
Fantin A, Tacconi C, Villa E, Ceccacci E, Denti L, Ruhrberg C. Fantin A, et al. Among authors: ceccacci e. Front Cell Dev Biol. 2021 Jul 29;9:648630. doi: 10.3389/fcell.2021.648630. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34395414 Free PMC article.
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S. Ravasio R, et al. Among authors: ceccacci e. Sci Adv. 2020 Apr 8;6(15):eaax2746. doi: 10.1126/sciadv.aax2746. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32284990 Free PMC article.