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Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance.
Eur J Pharm Biopharm. 2006 Jul;63(3):347-55. doi: 10.1016/j.ejpb.2006.01.014. Epub 2006 Feb 23.
Eur J Pharm Biopharm. 2006.
PMID: 16621491
HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
Cabrera AC, Melo E, Roth D, Topp A, Delobel F, Stucki C, Chen CY, Jakob P, Banfai B, Dunkley T, Schilling O, Huber S, Iacone R, Petrone P.
Cabrera AC, et al. Among authors: delobel f.
Sci Rep. 2017 Nov 1;7(1):14804. doi: 10.1038/s41598-017-14208-z.
Sci Rep. 2017.
PMID: 29093542
Free PMC article.
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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.
Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, Cabrera AC, Chen CY, Hoflack JC, Kam-Thong T, Schmucki R, Badi L, Flint N, Ghiani ZE, Delobel F, Stucki C, Gromo G, Einhaus A, Hornsperger B, Golling S, Siebourg-Polster J, Gerber F, Bohrmann B, Futter C, Dunkley T, Hiller S, Schilling O, Enzmann V, Fauser S, Plodinec M, Iacone R.
Melo E, et al. Among authors: delobel f.
EBioMedicine. 2018 Jan;27:258-274. doi: 10.1016/j.ebiom.2017.12.011. Epub 2017 Dec 13.
EBioMedicine. 2018.
PMID: 29269042
Free PMC article.
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N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.
Chen CY, Melo E, Jakob P, Friedlein A, Elsässer B, Goettig P, Kueppers V, Delobel F, Stucki C, Dunkley T, Fauser S, Schilling O, Iacone R.
Chen CY, et al. Among authors: delobel f.
Matrix Biol. 2018 Sep;70:84-101. doi: 10.1016/j.matbio.2018.03.013. Epub 2018 Mar 20.
Matrix Biol. 2018.
PMID: 29572155
Free article.
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Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.
Drawnel FM, Boccardo S, Prummer M, Delobel F, Graff A, Weber M, Gérard R, Badi L, Kam-Thong T, Bu L, Jiang X, Hoflack JC, Kiialainen A, Jeworutzki E, Aoyama N, Carlson C, Burcin M, Gromo G, Boehringer M, Stahlberg H, Hall BJ, Magnone MC, Kolaja K, Chien KR, Bailly J, Iacone R.
Drawnel FM, et al. Among authors: delobel f.
Cell Rep. 2014 Nov 6;9(3):810-21. doi: 10.1016/j.celrep.2014.09.055. Epub 2014 Oct 30.
Cell Rep. 2014.
PMID: 25437537
Free article.
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Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
Drawnel FM, Zhang JD, Küng E, Aoyama N, Benmansour F, Araujo Del Rosario A, Jensen Zoffmann S, Delobel F, Prummer M, Weibel F, Carlson C, Anson B, Iacone R, Certa U, Singer T, Ebeling M, Prunotto M.
Drawnel FM, et al. Among authors: delobel f.
Cell Chem Biol. 2017 May 18;24(5):624-634.e3. doi: 10.1016/j.chembiol.2017.03.016. Epub 2017 Apr 20.
Cell Chem Biol. 2017.
PMID: 28434878
Free article.
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Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes.
Blanchard N, Richert L, Notter B, Delobel F, David P, Coassolo P, Lavé T.
Blanchard N, et al. Among authors: delobel f.
Eur J Pharm Sci. 2004 Oct;23(2):189-99. doi: 10.1016/j.ejps.2004.07.007.
Eur J Pharm Sci. 2004.
PMID: 15451007
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