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2020 | 1 |
2022 | 2 |
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Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2.
Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2212931120. doi: 10.1073/pnas.2212931120. Epub 2023 Jan 4.
Proc Natl Acad Sci U S A. 2023.
PMID: 36598939
Free PMC article.
Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2.
O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A.
O'Leary PC, et al. Among authors: doruk yu.
Cancer Res. 2022 Nov 2;82(21):3950-3961. doi: 10.1158/0008-5472.CAN-21-4335.
Cancer Res. 2022.
PMID: 36273492
Free PMC article.
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Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2.
Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko D, Moroz Y, Irwin JJ, Renslo AR, Taylor JC, Gestwicki JE, von Delft F, Ashworth A, Ahel I, Shoichet BK, Fraser JS.
Gahbauer S, et al. Among authors: doruk yu.
bioRxiv [Preprint]. 2022 Jul 28:2022.06.27.497816. doi: 10.1101/2022.06.27.497816.
bioRxiv. 2022.
PMID: 35794891
Free PMC article.
Updated.
Preprint.
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A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude.
Doruk YU, Yarparvar D, Akyel YK, Gul S, Taskin AC, Yilmaz F, Baris I, Ozturk N, Türkay M, Ozturk N, Okyar A, Kavakli IH.
Doruk YU, et al.
J Biol Chem. 2020 Mar 13;295(11):3518-3531. doi: 10.1074/jbc.RA119.011332. Epub 2020 Feb 4.
J Biol Chem. 2020.
PMID: 32019867
Free PMC article.
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