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Page 1
Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging.
Nat Aging. 2023 Jul;3(7):796-812. doi: 10.1038/s43587-023-00436-8. Epub 2023 Jun 5.
Nat Aging. 2023.
PMID: 37277641
Free PMC article.
Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity.
Schappe MS, Stremska ME, Busey GW, Downs TK, Seegren PV, Mendu SK, Flegal Z, Doyle CA, Stipes EJ, Desai BN.
Schappe MS, et al. Among authors: downs tk.
Nat Commun. 2022 Jun 9;13(1):3230. doi: 10.1038/s41467-022-30959-4.
Nat Commun. 2022.
PMID: 35680919
Free PMC article.
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Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing.
Seegren PV, Downs TK, Stremska ME, Harper LR, Cao R, Olson RJ, Upchurch CM, Doyle CA, Kennedy J, Stipes EL, Leitinger N, Periasamy A, Desai BN.
Seegren PV, et al. Among authors: downs tk.
Cell Rep. 2020 Nov 24;33(8):108411. doi: 10.1016/j.celrep.2020.108411.
Cell Rep. 2020.
PMID: 33238121
Free PMC article.
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Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
Cuddy SR, Schinlever AR, Dochnal S, Seegren PV, Suzich J, Kundu P, Downs TK, Farah M, Desai BN, Boutell C, Cliffe AR.
Cuddy SR, et al. Among authors: downs tk.
Elife. 2020 Dec 22;9:e58037. doi: 10.7554/eLife.58037.
Elife. 2020.
PMID: 33350386
Free PMC article.
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Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Schappe MS, Szteyn K, Stremska ME, Mendu SK, Downs TK, Seegren PV, Mahoney MA, Dixit S, Krupa JK, Stipes EJ, Rogers JS, Adamson SE, Leitinger N, Desai BN.
Schappe MS, et al. Among authors: downs tk.
Immunity. 2018 Jan 16;48(1):59-74.e5. doi: 10.1016/j.immuni.2017.11.026.
Immunity. 2018.
PMID: 29343440
Free PMC article.
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