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Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J. Eysert F, et al. Among authors: flaig a. Mol Psychiatry. 2021 Oct;26(10):5592-5607. doi: 10.1038/s41380-020-00926-w. Epub 2020 Nov 3. Mol Psychiatry. 2021. PMID: 33144711 Free PMC article.
Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.
Kilinc D, Vreulx AC, Mendes T, Flaig A, Marques-Coelho D, Verschoore M, Demiautte F, Amouyel P; Neuro-CEB Brain Bank; Eysert F, Dourlen P, Chapuis J, Costa MR, Malmanche N, Checler F, Lambert JC. Kilinc D, et al. Among authors: flaig a. Brain Commun. 2020 Aug 28;2(2):fcaa139. doi: 10.1093/braincomms/fcaa139. eCollection 2020. Brain Commun. 2020. PMID: 33718872 Free PMC article.
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.
Sartori M, Mendes T, Desai S, Lasorsa A, Herledan A, Malmanche N, Mäkinen P, Marttinen M, Malki I, Chapuis J, Flaig A, Vreulx AC, Ciancia M, Amouyel P, Leroux F, Déprez B, Cantrelle FX, Maréchal D, Pradier L, Hiltunen M, Landrieu I, Kilinc D, Herault Y, Laporte J, Lambert JC. Sartori M, et al. Among authors: flaig a. Acta Neuropathol. 2019 Oct;138(4):631-652. doi: 10.1007/s00401-019-02017-9. Epub 2019 May 7. Acta Neuropathol. 2019. PMID: 31065832 Free PMC article.
Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.
Hermant X, Delay C, Flaig A, Luque-Bedregal J, Briand G, Bout MA, Cottel D, Wagner A, Arveiler D, Simon C, Ferrières J, Ruidavets JB, Laillet B, Amouyel P, Dallongeville J, Meirhaeghe A, Dumont J. Hermant X, et al. Among authors: flaig a. J Clin Lipidol. 2018 Sep-Oct;12(5):1280-1289. doi: 10.1016/j.jacl.2018.07.012. Epub 2018 Jul 31. J Clin Lipidol. 2018. PMID: 30170993
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O'Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC; ADGC, Alzheimer’s Disease Neuroimaging Initiative. Chapuis J, et al. Among authors: flaig a. Acta Neuropathol. 2017 Jun;133(6):955-966. doi: 10.1007/s00401-016-1652-z. Epub 2016 Dec 8. Acta Neuropathol. 2017. PMID: 27933404 Free PMC article.
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
Letronne F, Laumet G, Ayral AM, Chapuis J, Demiautte F, Laga M, Vandenberghe ME, Malmanche N, Leroux F, Eysert F, Sottejeau Y, Chami L, Flaig A, Bauer C, Dourlen P, Lesaffre M, Delay C, Huot L, Dumont J, Werkmeister E, Lafont F, Mendes T, Hansmannel F, Dermaut B, Deprez B, Hérard AS, Dhenain M, Souedet N, Pasquier F, Tulasne D, Berr C, Hauw JJ, Lemoine Y, Amouyel P, Mann D, Déprez R, Checler F, Hot D, Delzescaux T, Gevaert K, Lambert JC. Letronne F, et al. Among authors: flaig a. EBioMedicine. 2016 Jul;9:278-292. doi: 10.1016/j.ebiom.2016.06.002. Epub 2016 Jun 2. EBioMedicine. 2016. PMID: 27333034 Free PMC article.
Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.
Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J. Eysert F, et al. Among authors: flaig a. Mol Psychiatry. 2021 Oct;26(10):5608. doi: 10.1038/s41380-020-01015-8. Mol Psychiatry. 2021. PMID: 33398090 Free PMC article. No abstract available.
Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain.
Sottejeau Y, Bretteville A, Cantrelle FX, Malmanche N, Demiaute F, Mendes T, Delay C, Alves Dos Alves H, Flaig A, Davies P, Dourlen P, Dermaut B, Laporte J, Amouyel P, Lippens G, Chapuis J, Landrieu I, Lambert JC. Sottejeau Y, et al. Among authors: flaig a. Acta Neuropathol Commun. 2015 Sep 23;3:58. doi: 10.1186/s40478-015-0237-8. Acta Neuropathol Commun. 2015. PMID: 26395440 Free PMC article.