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Page 1
Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy.
Sci Transl Med. 2022 Jul 6;14(652):eabl5654. doi: 10.1126/scitranslmed.abl5654. Epub 2022 Jul 6.
Sci Transl Med. 2022.
PMID: 35857625
Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice.
Ranjbarvaziri S, Zeng A, Wu I, Greer-Short A, Farshidfar F, Budan A, Xu E, Shenwai R, Kozubov M, Li C, Van Pell M, Grafton F, MacKay CE, Song X, Priest JR, Argast G, Mandegar MA, Hoey T, Yang J.
Ranjbarvaziri S, et al. Among authors: grafton f.
Nat Commun. 2024 Feb 26;15(1):1352. doi: 10.1038/s41467-024-45440-7.
Nat Commun. 2024.
PMID: 38409164
Free PMC article.
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Harnessing Colon Chip Technology to Identify Commensal Bacteria That Promote Host Tolerance to Infection.
Gazzaniga FS, Camacho DM, Wu M, Silva Palazzo MF, Dinis ALM, Grafton FN, Cartwright MJ, Super M, Kasper DL, Ingber DE.
Gazzaniga FS, et al. Among authors: grafton fn.
Front Cell Infect Microbiol. 2021 Mar 12;11:638014. doi: 10.3389/fcimb.2021.638014. eCollection 2021.
Front Cell Infect Microbiol. 2021.
PMID: 33777849
Free PMC article.
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Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes.
Grafton F, Ho J, Ranjbarvaziri S, Farshidfar F, Budan A, Steltzer S, Maddah M, Loewke KE, Green K, Patel S, Hoey T, Mandegar MA.
Grafton F, et al.
Elife. 2021 Aug 2;10:e68714. doi: 10.7554/eLife.68714.
Elife. 2021.
PMID: 34338636
Free PMC article.
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Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method.
Maddah M, Mandegar MA, Dame K, Grafton F, Loewke K, Ribeiro AJS.
Maddah M, et al. Among authors: grafton f.
J Pharmacol Toxicol Methods. 2020 Sep;105:106895. doi: 10.1016/j.vascn.2020.106895. Epub 2020 Jul 3.
J Pharmacol Toxicol Methods. 2020.
PMID: 32629158
Free article.
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