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The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.
Pancreatology. 2018 Jan;18(1):12-19. doi: 10.1016/j.pan.2017.12.001. Epub 2017 Dec 5.
Pancreatology. 2018.
PMID: 29233499
Review.
The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.
Fjeld K, Gravdal A, Brekke RS, Alam J, Wilhelm SJ, El Jellas K, Pettersen HN, Lin J, Solheim MH, Steine SJ, Johansson BB, Njølstad PR, Verbeke CS, Xiao X, Lowe ME, Molven A.
Fjeld K, et al. Among authors: gravdal a.
Pancreatology. 2022 Dec;22(8):1099-1111. doi: 10.1016/j.pan.2022.11.003. Epub 2022 Nov 9.
Pancreatology. 2022.
PMID: 36379850
Free article.
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Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis.
Tjora E, Gravdal A, Engjom T, Cnop M, Johansson BB, Dimcevski GG, Molven A, Fjeld K.
Tjora E, et al. Among authors: gravdal a.
Eur J Gastroenterol Hepatol. 2021 Jun 1;33(6):839-843. doi: 10.1097/MEG.0000000000001963.
Eur J Gastroenterol Hepatol. 2021.
PMID: 33079780
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Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas.
Brekke RS, Gravdal A, El Jellas K, Curry GE, Lin J, Wilhelm SJ, Steine SJ, Mas E, Johansson S, Lowe ME, Johansson BB, Xiao X, Fjeld K, Molven A.
Brekke RS, et al. Among authors: gravdal a.
Hum Mol Genet. 2024 Mar 14:ddae034. doi: 10.1093/hmg/ddae034. Online ahead of print.
Hum Mol Genet. 2024.
PMID: 38483348
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Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells.
Dalva M, Lavik IK, El Jellas K, Gravdal A, Lugea A, Pandol SJ, Njølstad PR, Waldron RT, Fjeld K, Johansson BB, Molven A.
Dalva M, et al. Among authors: gravdal a.
Cells. 2020 Jan 18;9(1):244. doi: 10.3390/cells9010244.
Cells. 2020.
PMID: 31963687
Free PMC article.
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The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.
Gravdal A, Xiao X, Cnop M, El Jellas K, Johansson S, Njølstad PR, Lowe ME, Johansson BB, Molven A, Fjeld K.
Gravdal A, et al.
J Biol Chem. 2021 Jan-Jun;296:100661. doi: 10.1016/j.jbc.2021.100661. Epub 2021 Apr 14.
J Biol Chem. 2021.
PMID: 33862081
Free PMC article.
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Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis.
Fjeld K, Masson E, Lin JH, Michl P, Stokowy T, Gravdal A, El Jellas K, Steine SJ, Hoem D, Johansson BB, Dalva M, Ruffert C, Zou WB, Li ZS, Njølstad PR, Chen JM, Liao Z, Johansson S, Rosendahl J, Férec C, Molven A.
Fjeld K, et al. Among authors: gravdal a.
Pancreatology. 2020 Apr;20(3):377-384. doi: 10.1016/j.pan.2020.01.011. Epub 2020 Jan 20.
Pancreatology. 2020.
PMID: 32007358
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