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TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice.
Surme S, Ergun C, Gul S, Akyel YK, Gul ZM, Ozcan O, Ipek OS, Akarlar BA, Ozlu N, Taskin AC, Turkay M, Gören AC, Baris I, Ozturk N, Guzel M, Aydin C, Okyar A, Kavakli IH. Surme S, et al. Among authors: gul zm. Biochem Pharmacol. 2023 Dec;218:115896. doi: 10.1016/j.bcp.2023.115896. Epub 2023 Oct 28. Biochem Pharmacol. 2023. PMID: 37898388
Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice.
Gul S, Akyel YK, Gul ZM, Isin S, Ozcan O, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Akarlar BA, Ozlu N, Ozturk N, Ozturk N, Ünal DÖ, Guzel M, Turkay M, Okyar A, Kavakli IH. Gul S, et al. Among authors: gul zm. Nat Commun. 2022 Nov 8;13(1):6742. doi: 10.1038/s41467-022-34582-1. Nat Commun. 2022. PMID: 36347873 Free PMC article.