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HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter.
Antimicrob Agents Chemother. 2018 Jun 26;62(7):e02459-17. doi: 10.1128/AAC.02459-17. Print 2018 Jul.
Antimicrob Agents Chemother. 2018.
PMID: 29661875
Free PMC article.
Discovery and characterization of antimycobacterial nitro-containing compounds with distinct mechanisms of action and in vivo efficacy.
Eke IE, Williams JT, Haiderer ER, Albrecht VJ, Murdoch HM, Abdalla BJ, Abramovitch RB.
Eke IE, et al. Among authors: haiderer er.
Antimicrob Agents Chemother. 2023 Sep 19;67(9):e0047423. doi: 10.1128/aac.00474-23. Epub 2023 Aug 23.
Antimicrob Agents Chemother. 2023.
PMID: 37610224
Free PMC article.
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The Mycobacterium tuberculosis MmpL3 inhibitor MSU-43085 is active in a mouse model of infection.
Williams JT, Giletto M, Haiderer ER, Aleiwi B, Krieger-Burke T, Ellsworth E, Abramovitch RB.
Williams JT, et al. Among authors: haiderer er.
Microbiol Spectr. 2024 Jan 11;12(1):e0367723. doi: 10.1128/spectrum.03677-23. Epub 2023 Dec 11.
Microbiol Spectr. 2024.
PMID: 38078724
Free PMC article.
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Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics.
Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB.
Coulson GB, et al. Among authors: haiderer er.
Cell Chem Biol. 2017 Aug 17;24(8):993-1004.e4. doi: 10.1016/j.chembiol.2017.06.018. Epub 2017 Aug 3.
Cell Chem Biol. 2017.
PMID: 28781126
Free PMC article.
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Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance.
Williams JT, Haiderer ER, Coulson GB, Conner KN, Ellsworth E, Chen C, Alvarez-Cabrera N, Li W, Jackson M, Dick T, Abramovitch RB.
Williams JT, et al. Among authors: haiderer er.
Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00547-19. doi: 10.1128/AAC.00547-19. Print 2019 Oct.
Antimicrob Agents Chemother. 2019.
PMID: 31405862
Free PMC article.
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