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An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase.
Berneburg I, Peddibhotla S, Heimsch KC, Haeussler K, Maloney P, Gosalia P, Preuss J, Rahbari M, Skorokhod O, Valente E, Ulliers D, Simula LF, Buchholz K, Hedrick MP, Hershberger P, Chung TDY, Jackson MR, Schwarzer E, Rahlfs S, Bode L, Becker K, Pinkerton AB. Berneburg I, et al. Among authors: heimsch kc. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0210921. doi: 10.1128/aac.02109-21. Epub 2022 Mar 10. Antimicrob Agents Chemother. 2022. PMID: 35266827 Free PMC article.
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Gnädig NF, Stokes BH, Edwards RL, Kalantarov GF, Heimsch KC, Kuderjavy M, Crane A, Lee MCS, Straimer J, Becker K, Trakht IN, Odom John AR, Mok S, Fidock DA. Gnädig NF, et al. Among authors: heimsch kc. PLoS Pathog. 2020 Apr 20;16(4):e1008482. doi: 10.1371/journal.ppat.1008482. eCollection 2020 Apr. PLoS Pathog. 2020. PMID: 32310999 Free PMC article.
Plasmodium falciparum Ferredoxin-NADP+ Reductase-Catalyzed Redox Cycling of Plasmodione Generates Both Predicted Key Drug Metabolites: Implication for Antimalarial Drug Development.
Cichocki BA, Donzel M, Heimsch KC, Lesanavičius M, Feng L, Montagut EJ, Becker K, Aliverti A, Elhabiri M, Čėnas N, Davioud-Charvet E. Cichocki BA, et al. Among authors: heimsch kc. ACS Infect Dis. 2021 Jul 9;7(7):1996-2012. doi: 10.1021/acsinfecdis.1c00054. Epub 2021 Apr 15. ACS Infect Dis. 2021. PMID: 33855850