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A comprehensive platform for analyzing longitudinal multi-omics data.
Vasaikar SV, Savage AK, Gong Q, Swanson E, Talla A, Lord C, Heubeck AT, Reading J, Graybuck LT, Meijer P, Torgerson TR, Skene PJ, Bumol TF, Li XJ. Vasaikar SV, et al. Among authors: heubeck at. Nat Commun. 2023 Mar 27;14(1):1684. doi: 10.1038/s41467-023-37432-w. Nat Commun. 2023. PMID: 36973282 Free PMC article.
Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment.
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li XJ, Bumol TF, Wherry EJ, Torgerson TR, Vella LA, Henrickson SE, Skene PJ, Gustafson CE. Thomson Z, et al. Among authors: heubeck at. Nat Immunol. 2023 Nov;24(11):1947-1959. doi: 10.1038/s41590-023-01641-8. Epub 2023 Oct 16. Nat Immunol. 2023. PMID: 37845489 Free PMC article.
Optimized workflow for human PBMC multiomic immunosurveillance studies.
Genge PC, Roll CR, Heubeck AT, Swanson E, Kondza N, Lord C, Weiss M, Hernandez V, Phalen C, Thomson Z, Torgerson TR, Skene PJ, Bumol TF, Reading J. Genge PC, et al. Among authors: heubeck at. STAR Protoc. 2021 Nov 5;2(4):100900. doi: 10.1016/j.xpro.2021.100900. eCollection 2021 Dec 17. STAR Protoc. 2021. PMID: 34806044 Free PMC article.
Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistence.
Talla A, Vasaikar SV, Lemos MP, Moodie Z, Lee Pebworth MP, Henderson KE, Cohen KW, Czartoski JL, Lai L, Suthar MS, Heubeck AT, Genge PC, Roll CR, Weiss M, Reading J, Kondza N, MacMillan H, Fong OC, Thomson ZJ, Graybuck LT, Okada LY, Newell EW, Coffey EM, Meijer P, Becker LA, De Rosa SC, Skene PJ, Torgerson TR, Li XJ, Szeto GL, McElrath MJ, Bumol TF. Talla A, et al. Among authors: heubeck at. bioRxiv [Preprint]. 2021 Aug 19:2021.05.26.442666. doi: 10.1101/2021.05.26.442666. bioRxiv. 2021. PMID: 34075380 Free PMC article. Preprint.
Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing.
Savage AK, Gutschow MV, Chiang T, Henderson K, Green R, Chaudhari M, Swanson E, Heubeck AT, Kondza N, Burley KC, Genge PC, Lord C, Smith T, Thomson Z, Beaubien A, Johnson E, Goldy J, Bolouri H, Buckner JH, Meijer P, Coffey EM, Skene PJ, Torgerson TR, Li XJ, Bumol TF. Savage AK, et al. Among authors: heubeck at. iScience. 2021 Apr 15;24(5):102404. doi: 10.1016/j.isci.2021.102404. eCollection 2021 May 21. iScience. 2021. PMID: 34113805 Free PMC article.
Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion.
Wienand K, Chapuy B, Stewart C, Dunford AJ, Wu D, Kim J, Kamburov A, Wood TR, Cader FZ, Ducar MD, Thorner AR, Nag A, Heubeck AT, Buonopane MJ, Redd RA, Bojarczuk K, Lawton LN, Armand P, Rodig SJ, Fromm JR, Getz G, Shipp MA. Wienand K, et al. Among authors: heubeck at. Blood Adv. 2019 Dec 10;3(23):4065-4080. doi: 10.1182/bloodadvances.2019001012. Blood Adv. 2019. PMID: 31816062 Free PMC article.
Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment.
Thomson Z, He Z, Swanson E, Henderson K, Phalen C, Zaim SR, Pebworth MP, Okada LY, Heubeck AT, Roll CR, Hernandez V, Weiss M, Genge PC, Reading J, Giles JR, Manne S, Dougherty J, Jasen CJ, Greenplate AR, Becker LA, Graybuck LT, Vasaikar SV, Szeto GL, Savage AK, Speake C, Buckner JH, Li XJ, Bumol TF, Wherry EJ, Torgerson TR, Vella LA, Henrickson SE, Skene PJ, Gustafson CE. Thomson Z, et al. Among authors: heubeck at. Nat Immunol. 2024 Mar;25(3):577. doi: 10.1038/s41590-024-01757-5. Nat Immunol. 2024. PMID: 38267693 Free PMC article. No abstract available.