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Year Number of Results
2006 1
2009 1
2010 1
2011 1
2015 1
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2021 5
2022 7
2023 8
2024 2

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Page 1
Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.
Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Higashi-Kuwata N, et al. Nat Commun. 2023 Feb 25;14(1):1076. doi: 10.1038/s41467-023-36729-0. Nat Commun. 2023. PMID: 36841831 Free PMC article.
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
Aoki M, Aoki-Ogata H, Bulut H, Hayashi H, Takamune N, Kishimoto N, Tanaka H, Higashi-Kuwata N, Hattori SI, Das D, Venkateswara Rao K, Iwama K, Davis DA, Hasegawa K, Murayama K, Yarchoan R, Ghosh AK, Pau AK, Machida S, Misumi S, Mitsuya H. Aoki M, et al. Among authors: higashi kuwata n. Sci Adv. 2023 Jul 14;9(28):eadg2955. doi: 10.1126/sciadv.adg2955. Epub 2023 Jul 12. Sci Adv. 2023. PMID: 37436982 Free PMC article.
Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma.
Maeda K, Higashi-Kuwata N, Kinoshita N, Kutsuna S, Tsuchiya K, Hattori SI, Matsuda K, Takamatsu Y, Gatanaga H, Oka S, Sugiyama H, Ohmagari N, Mitsuya H. Maeda K, et al. Among authors: higashi kuwata n. Sci Rep. 2021 Mar 10;11(1):5563. doi: 10.1038/s41598-021-84733-5. Sci Rep. 2021. PMID: 33692457 Free PMC article.
Potent and biostable inhibitors of the main protease of SARS-CoV-2.
Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H. Tsuji K, et al. Among authors: higashi kuwata n. iScience. 2022 Nov 18;25(11):105365. doi: 10.1016/j.isci.2022.105365. Epub 2022 Nov 1. iScience. 2022. PMID: 36338434 Free PMC article.
Highly Neutralizing COVID-19 Convalescent Plasmas Potently Block SARS-CoV-2 Replication and Pneumonia in Syrian Hamsters.
Takamatsu Y, Imai M, Maeda K, Nakajima N, Higashi-Kuwata N, Iwatsuki-Horimoto K, Ito M, Kiso M, Maemura T, Takeda Y, Omata K, Suzuki T, Kawaoka Y, Mitsuya H. Takamatsu Y, et al. Among authors: higashi kuwata n. J Virol. 2022 Feb 23;96(4):e0155121. doi: 10.1128/JVI.01551-21. Epub 2021 Nov 24. J Virol. 2022. PMID: 34818068 Free PMC article.
Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.
Higashi-Kuwata N, Hayashi S, Kumamoto H, Ogata-Aoki H, Das D, Venzon D, Hattori SI, Bulut H, Hashimoto M, Otagiri M, Takamune N, Kishimoto N, Davis DA, Misumi S, Kakuni M, Tanaka Y, Mitsuya H. Higashi-Kuwata N, et al. J Hepatol. 2021 May;74(5):1075-1086. doi: 10.1016/j.jhep.2020.12.006. Epub 2020 Dec 15. J Hepatol. 2021. PMID: 33333207 Free PMC article.
32 results