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Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.
Science. 2021 Jan 29;371(6528):eabc8059. doi: 10.1126/science.abc8059. Epub 2020 Dec 10.
Science. 2021.
PMID: 33303683
Free PMC article.
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration.
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM.
Porpiglia E, et al. Among authors: holbrook ca.
Cell Stem Cell. 2022 Dec 1;29(12):1653-1668.e8. doi: 10.1016/j.stem.2022.10.009. Epub 2022 Nov 15.
Cell Stem Cell. 2022.
PMID: 36384141
Free PMC article.
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Biophysical matrix cues from the regenerating niche direct muscle stem cell fate in engineered microenvironments.
Madl CM, Flaig IA, Holbrook CA, Wang YX, Blau HM.
Madl CM, et al. Among authors: holbrook ca.
Biomaterials. 2021 Aug;275:120973. doi: 10.1016/j.biomaterials.2021.120973. Epub 2021 Jun 14.
Biomaterials. 2021.
PMID: 34224984
Free PMC article.
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Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors.
Togninalli M, Ho ATV, Madl CM, Holbrook CA, Wang YX, Magnusson KEG, Kirillova A, Chang A, Blau HM.
Togninalli M, et al. Among authors: holbrook ca.
NPJ Regen Med. 2023 Jan 14;8(1):4. doi: 10.1038/s41536-023-00277-4.
NPJ Regen Med. 2023.
PMID: 36639373
Free PMC article.
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Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength.
Ho ATV, Palla AR, Blake MR, Yucel ND, Wang YX, Magnusson KEG, Holbrook CA, Kraft PE, Delp SL, Blau HM.
Ho ATV, et al. Among authors: holbrook ca.
Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6675-6684. doi: 10.1073/pnas.1705420114. Epub 2017 Jun 12.
Proc Natl Acad Sci U S A. 2017.
PMID: 28607093
Free PMC article.
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