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Biomolecular Condensates as Novel Antiviral Targets.
Martin EW, Iserman C, Olety B, Mitrea DM, Klein IA. Martin EW, et al. Among authors: iserman c. J Mol Biol. 2024 Feb 15;436(4):168380. doi: 10.1016/j.jmb.2023.168380. Epub 2023 Dec 5. J Mol Biol. 2024. PMID: 38061626 Review.
Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.
Roden CA, Dai Y, Giannetti CA, Seim I, Lee M, Sealfon R, McLaughlin GA, Boerneke MA, Iserman C, Wey SA, Ekena JL, Troyanskaya OG, Weeks KM, You L, Chilkoti A, Gladfelter AS. Roden CA, et al. Among authors: iserman c. Nucleic Acids Res. 2022 Aug 12;50(14):8168-8192. doi: 10.1093/nar/gkac596. Nucleic Acids Res. 2022. PMID: 35871289 Free PMC article.
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.
Iserman C, Roden CA, Boerneke MA, Sealfon RSG, McLaughlin GA, Jungreis I, Fritch EJ, Hou YJ, Ekena J, Weidmann CA, Theesfeld CL, Kellis M, Troyanskaya OG, Baric RS, Sheahan TP, Weeks KM, Gladfelter AS. Iserman C, et al. Mol Cell. 2020 Dec 17;80(6):1078-1091.e6. doi: 10.1016/j.molcel.2020.11.041. Epub 2020 Nov 27. Mol Cell. 2020. PMID: 33290746 Free PMC article.
Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production.
Iserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kramer G, Kreysing M, Franzmann TM, Alberti S. Iserman C, et al. Cell. 2020 May 14;181(4):818-831.e19. doi: 10.1016/j.cell.2020.04.009. Epub 2020 Apr 30. Cell. 2020. PMID: 32359423 Free PMC article.
Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate.
Iserman C, Roden C, Boerneke M, Sealfon R, McLaughlin G, Jungreis I, Park C, Boppana A, Fritch E, Hou YJ, Theesfeld C, Troyanskaya OG, Baric RS, Sheahan TP, Weeks K, Gladfelter AS. Iserman C, et al. bioRxiv [Preprint]. 2020 Jun 12:2020.06.11.147199. doi: 10.1101/2020.06.11.147199. bioRxiv. 2020. PMID: 32587965 Free PMC article. Preprint.
Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.
Roden CA, Dai Y, Seim I, Lee M, Sealfon R, McLaughlin GA, Boerneke MA, Iserman C, Wey SA, Ekena JL, Troyanskaya OG, Weeks KM, You L, Chilkoti A, Gladfelter AS. Roden CA, et al. Among authors: iserman c. bioRxiv [Preprint]. 2021 Jun 15:2021.06.14.448452. doi: 10.1101/2021.06.14.448452. bioRxiv. 2021. PMID: 34159327 Free PMC article. Updated. Preprint.