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Page 1
Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.
van Welsem T, Korthout T, Ekkebus R, Morais D, Molenaar TM, van Harten K, Poramba-Liyanage DW, Sun SM, Lenstra TL, Srivas R, Ideker T, Holstege FCP, van Attikum H, El Oualid F, Ovaa H, Stulemeijer IJE, Vlaming H, van Leeuwen F. van Welsem T, et al. Among authors: korthout t. Nucleic Acids Res. 2018 Nov 30;46(21):11251-11261. doi: 10.1093/nar/gky801. Nucleic Acids Res. 2018. PMID: 30203048 Free PMC article.
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.
Kwesi-Maliepaard EM, Aslam MA, Alemdehy MF, van den Brand T, McLean C, Vlaming H, van Welsem T, Korthout T, Lancini C, Hendriks S, Ahrends T, van Dinther D, den Haan JMM, Borst J, de Wit E, van Leeuwen F, Jacobs H. Kwesi-Maliepaard EM, et al. Among authors: korthout t. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20706-20716. doi: 10.1073/pnas.1920372117. Epub 2020 Aug 6. Proc Natl Acad Sci U S A. 2020. PMID: 32764145 Free PMC article.
Combinatorial single-cell profiling of major chromatin types with MAbID.
Lochs SJA, van der Weide RH, de Luca KL, Korthout T, van Beek RE, Kimura H, Kind J. Lochs SJA, et al. Among authors: korthout t. Nat Methods. 2024 Jan;21(1):72-82. doi: 10.1038/s41592-023-02090-9. Epub 2023 Dec 4. Nat Methods. 2024. PMID: 38049699 Free PMC article.
Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.
Poramba-Liyanage DW, Korthout T, Cucinotta CE, van Kruijsbergen I, van Welsem T, El Atmioui D, Ovaa H, Tsukiyama T, van Leeuwen F. Poramba-Liyanage DW, et al. Among authors: korthout t. Genome Res. 2020 Apr;30(4):635-646. doi: 10.1101/gr.256255.119. Epub 2020 Mar 18. Genome Res. 2020. PMID: 32188699 Free PMC article.
Decoding the chromatin proteome of a single genomic locus by DNA sequencing.
Korthout T, Poramba-Liyanage DW, van Kruijsbergen I, Verzijlbergen KF, van Gemert FPA, van Welsem T, van Leeuwen F. Korthout T, et al. PLoS Biol. 2018 Jul 13;16(7):e2005542. doi: 10.1371/journal.pbio.2005542. eCollection 2018 Jul. PLoS Biol. 2018. PMID: 30005073 Free PMC article.
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.
Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F. Vlaming H, et al. Among authors: korthout t. EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17. EMBO J. 2019. PMID: 31304633 Free PMC article.