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A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease.
Canela VH, Bowen WS, Ferreira RM, Syed F, Lingeman JE, Sabo AR, Barwinska D, Winfree S, Lake BB, Cheng YH, Gaut JP, Ferkowicz M, LaFavers KA, Zhang K, Coe FL, Worcester E; Kidney Precision Medicine Project; Jain S, Eadon MT, Williams JC Jr, El-Achkar TM. Canela VH, et al. Among authors: lafavers ka. Nat Commun. 2023 Jul 19;14(1):4140. doi: 10.1038/s41467-023-38975-8. Nat Commun. 2023. PMID: 37468493 Free PMC article.
The kidney protects against sepsis by producing systemic uromodulin.
LaFavers KA, Hage CA, Gaur V, Micanovic R, Hato T, Khan S, Winfree S, Doshi S, Moorthi RN, Twigg H, Wu XR, Dagher PC, Srour EF, El-Achkar TM. LaFavers KA, et al. Am J Physiol Renal Physiol. 2022 Aug 1;323(2):F212-F226. doi: 10.1152/ajprenal.00146.2022. Epub 2022 Jun 27. Am J Physiol Renal Physiol. 2022. PMID: 35759740 Free PMC article.
Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.
Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Mansour SG, et al. Among authors: lafavers ka. Transplantation. 2021 Apr 1;105(4):876-885. doi: 10.1097/TP.0000000000003299. Transplantation. 2021. PMID: 32769629 Free PMC article.
The kidney releases a nonpolymerizing form of uromodulin in the urine and circulation that retains the external hydrophobic patch domain.
Micanovic R, LaFavers KA, Patidar KR, Ghabril MS, Doud EH, Mosley AL, Sabo AR, Khan S, El-Achkar TM. Micanovic R, et al. Among authors: lafavers ka. Am J Physiol Renal Physiol. 2022 Apr 1;322(4):F403-F418. doi: 10.1152/ajprenal.00322.2021. Epub 2022 Jan 31. Am J Physiol Renal Physiol. 2022. PMID: 35100812 Free PMC article.
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