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Page 1
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.
Kosti P, Opzoomer JW, Larios-Martinez KI, Henley-Smith R, Scudamore CL, Okesola M, Taher MYM, Davies DM, Muliaditan T, Larcombe-Young D, Woodman N, Gillett CE, Thavaraj S, Maher J, Arnold JN. Kosti P, et al. Among authors: larcombe young d. Cell Rep Med. 2021 Apr 9;2(4):100227. doi: 10.1016/j.xcrm.2021.100227. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948568 Free PMC article.
Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer.
Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, Marlow R, Francesch-Domenech E, Fittall M, Dominguez Rodriguez D, Clifford A, Badder L, Patel N, Mele S, Pellizzari G, Bax HJ, Crescioli S, Petranyi G, Larcombe-Young D, Josephs DH, Canevari S, Figini M, Pinder S, Nestle FO, Gillett C, Spicer JF, Grigoriadis A, Tutt ANJ, Karagiannis SN. Cheung A, et al. Among authors: larcombe young d. Clin Cancer Res. 2018 Oct 15;24(20):5098-5111. doi: 10.1158/1078-0432.CCR-18-0652. Epub 2018 Aug 1. Clin Cancer Res. 2018. PMID: 30068707 Free PMC article.
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors.
Muliaditan T, Halim L, Whilding LM, Draper B, Achkova DY, Kausar F, Glover M, Bechman N, Arulappu A, Sanchez J, Flaherty KR, Obajdin J, Grigoriadis K, Antoine P, Larcombe-Young D, Hull CM, Buus R, Gordon P, Grigoriadis A, Davies DM, Schurich A, Maher J. Muliaditan T, et al. Among authors: larcombe young d. Cell Rep Med. 2021 Dec 21;2(12):100457. doi: 10.1016/j.xcrm.2021.100457. eCollection 2021 Dec 21. Cell Rep Med. 2021. PMID: 35028604 Free PMC article.
Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs).
Hoffmann RM, Mele S, Cheung A, Larcombe-Young D, Bucaite G, Sachouli E, Zlatareva I, Morad HOJ, Marlow R, McDonnell JM, Figini M, Lacy KE, Tutt AJN, Spicer JF, Thurston DE, Karagiannis SN, Crescioli S. Hoffmann RM, et al. Among authors: larcombe young d. Sci Rep. 2020 Jun 1;10(1):8869. doi: 10.1038/s41598-020-65860-x. Sci Rep. 2020. PMID: 32483228 Free PMC article.